Prof. Isabelle Germano | Neurosurgery | Best Researcher Award
Professor at Icahn School of Medicine at Mount Sinai, United States
Dr. Isabelle M. Germano, MD, MBA, FACS, is an internationally recognized leader in neurosurgery, with a particular focus on neuro-oncology, stereotactic neurosurgery, and image-guided brain tumor surgery. As a Tenured Professor at the Icahn School of Medicine at Mount Sinai, she holds joint appointments in Neurosurgery, Neurology, and Oncological Sciences. Over a three-decade academic and clinical career, she has built and led Mount Sinai’s Comprehensive Brain Tumor Program, served as Co-Director of the Radiosurgery Program, and directed multiple fellowships in neuro-oncology. Dr. Germano is also a system-wide Vice Chair for Faculty Affairs and Diversity, Equity, and Inclusion, demonstrating her commitment to academic excellence and institutional transformation.
Profile
Education
Dr. Germano began her academic training at the Liceum Classicum M. D’Azeglio, where she studied classical languages before earning her MD with summa cum laude honors from the University of Turin Medical School. She completed a series of competitive and globally renowned post-doctoral fellowships, including neurosurgery at the University of California, San Francisco; epilepsy and functional neurosurgery at the University of Zurich and Montreal Neurological Institute; and chief residency at Albert Einstein College of Medicine. Seeking to bridge clinical science and systems leadership, she earned an MBA from NYU Stern School of Business (2015–2017), complementing her medical expertise with executive knowledge in healthcare economics and strategy.
Experience
Dr. Germano has been an active faculty member at Mount Sinai since 1993, advancing from Assistant Professor to full Tenured Professor by 2009. She has continuously served in critical leadership roles, including Chair of the Multidisciplinary Brain Tumor Board since 2003 and Co-Chair of the Spine Tumor Board since 2007. As Program Director of CAST and UCNS-accredited neuro-oncology fellowships and the CNS Foundation’s International Brain Tumor Fellowship, she has trained numerous global leaders in neurosurgery. Her administrative responsibilities expanded in 2023 with her appointment as System Vice-Chair for Faculty Affairs, following her prior leadership in DEI efforts.
Research Interests
Dr. Germano’s research integrates translational neuroscience, precision medicine, and technology-enabled surgery. Her interests include image-guided brain tumor resection, stem-cell-based therapy for gliomas, molecular oncology, and neurosurgical outcomes research. Recently, her investigations have focused on the intersection of racial disparities and outcomes in glioblastoma treatment, supported by NIH grants. She serves on editorial boards of Neuro-Oncology, Neuro-Oncology Advances, and World Neurosurgery, and frequently leads NIH/NCI and FDA panels. Her grant funding includes RO1s, R03s, and multiple foundation and industry-sponsored research initiatives.
Awards
Dr. Germano has received over 50 prestigious awards recognizing her clinical skill, leadership, innovation, and advocacy. She is the first woman to chair the AANS/CNS Section on Tumors and was named an Aspen Ideas Festival Panelist in 2024. Other honors include the AANS Leksell Radiosurgery Award, the Sundt Distinguished Lectureship at Mayo Clinic (2022), and the Culman Family Award for Physician Communication. She is consistently ranked among “New York SuperDoctors” and “America’s Top Doctors,” and was awarded Castle Connolly’s Hall of Fame distinction. In 2023, she received the Congress of Neurological Surgeons’ Inaugural International Fellowship for global neurosurgical leadership.
Publications
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Germano IM et al. “Closing the Gaps: Strategies to Improve Global Neurosurgical Subspecialty Care,” J Neurosurg, 2025, cited by 22 articles.
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Germano IM et al. “Navigating the Crossroads: Access to Care among Brain Tumor Patients,” J Neurosurg, 2024, cited by 31 articles.
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Germano IM et al. “Charting the Success of Neuronavigation in Brain Tumor Surgery,” J Neurooncol, 2024, cited by 45 articles.
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Germano IM et al. “Minimally Invasive Surgery for Metastatic Spine Disease: A Decade Review,” Neuro-Oncology, 2024, cited by 38 articles.
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Germano IM et al. “Enhanced Recovery After Brain Tumor Surgery: ERABTS Protocol,” Neurosurgery, 2025, cited by 17 articles.
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Germano IM et al. “Survival Predictions for WHO Grade II and III Gliomas via Machine Learning,” NPJ Digital Medicine, 2023, cited by 66 articles.
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Germano IM et al. “Adult Neuro-Oncology Trials in the US: 50-Year Review,” Neurooncol Adv, 2024, cited by 29 articles.
Conclusion
Dr. Isabelle M. Germano’s work spans the full arc of academic neurosurgery—clinical care, research, innovation, mentorship, and advocacy. As a physician-scientist and institutional leader, she continues to shape the future of neurosurgery through global engagement, equity-driven research, and technological advancement. Her legacy is distinguished not only by her pioneering work in neuro-oncology but by her commitment to building a more inclusive, effective, and compassionate medical community.