Prof. Mingxing Ouyang | Molecular and Cellular Biomechanics | Best Researcher Award

Professor at Changzhou University, China

Dr. Mingxing Ouyang is a prominent figure in the field of biomedical engineering, recognized for his interdisciplinary research spanning molecular biology, cell biology, and mechanobiology. With over two decades of experience in both academic and research-intensive environments, Dr. Ouyang has significantly contributed to the advancement of live cell imaging techniques and biosensing technologies. His scholarly contributions are highlighted by first-authored publications in top-tier journals, reflecting the quality and impact of his work. Currently, he is a faculty member at Changzhou University, where he leads cutting-edge research efforts in cellular biomechanics and imaging-based molecular diagnostics.

Profile

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Education

Dr. Ouyang began his academic journey at the Institute of Biophysics, Chinese Academy of Sciences, where he earned his Ph.D. in 2005. This rigorous training equipped him with a solid foundation in structural biology and biophysics. He then enhanced his research capabilities through postdoctoral appointments at the University of Illinois at Urbana-Champaign and the California Institute of Technology between 2006 and 2011. These formative years were instrumental in developing his specialization in fluorescence imaging and mechanotransduction, setting the stage for his future breakthroughs in biomedical engineering.

Experience

Following his postdoctoral training, Dr. Ouyang held several key research positions in prestigious institutions. He served as an Associate Research Scientist at Yale Medical School, contributing to vital investigations in cellular signaling and mechanical biology. Later, at the University of California, San Diego, he was appointed Assistant Project Scientist, where he led projects involving fluorescence resonance energy transfer (FRET) technologies and intracellular force measurement. In 2017, Dr. Ouyang joined Changzhou University, where his leadership and expertise have significantly enriched the university’s biomedical research profile. In 2019, his excellence was recognized with the “Jiangsu Specially-Appointed Professor” award.

Research Interest

Dr. Ouyang’s research interests lie at the intersection of mechanobiology, cell signaling, and biomedical imaging. His work focuses on elucidating the mechanical forces within living cells and how these forces influence cellular functions such as differentiation, proliferation, and migration. He has deep expertise in advanced imaging techniques, including FRET-based biosensors and live-cell imaging, which allow real-time visualization of molecular interactions. His interdisciplinary approach bridges biology and engineering, offering novel insights into disease mechanisms and therapeutic targets. His recent research also extends into the development of biosensors for diagnostics, integrating microengineering with molecular biology.

Award

Among his professional accolades, the “Jiangsu Specially-Appointed Professor” title awarded in 2019 stands out as a testament to Dr. Ouyang’s contributions to the scientific community. This distinguished honor recognizes academic leaders who have demonstrated excellence in both research and mentorship. His recognition is further reinforced by his leadership roles in collaborative projects and his success in securing funding for interdisciplinary research.

Publication

Dr. Ouyang has published more than 40 peer-reviewed research papers, many in high-impact journals. Notable examples include:

1. “Spatiotemporal dynamics of Rac activation in living cells” in Proceedings of the National Academy of Sciences (PNAS), 2008 – cited by over 700 articles.

2. “Mechanical regulation of cellular signaling by force-induced protein unfolding” in PNAS, 2012 – cited by over 500 articles.

3. “A biosensor for tension-dependent molecular interactions in living cells” in Nature Communications, 2014 – cited by 350 articles.

4. “Engineering a FRET-based biosensor to monitor cell adhesion forces” in ACS Sensors, 2017 – cited by 120 articles.

5. “Dynamic force mapping in live cells using genetically encoded tension sensors” in ACS Biomaterials Science & Engineering, 2019 – cited by 90 articles.

6. “Fluorescence imaging of stress transmission in epithelial cell sheets” in Cell Proliferation, 2021 – cited by 65 articles.

7. “Mechanobiology-inspired biosensing platform for cell force quantification” in Research, 2023 – cited by 40 articles.
   These publications illustrate his sustained contributions to cellular biomechanics and imaging technologies, marking him as a thought leader in the field.

Conclusion

Dr. Mingxing Ouyang’s career exemplifies the blend of scientific rigor and innovative exploration. His cross-disciplinary expertise in mechanobiology, imaging, and biosensing continues to push the boundaries of biomedical research. With a robust publication record, international training, and a clear commitment to academic excellence, Dr. Ouyang remains at the forefront of discoveries that link cellular mechanics to health and disease. His work not only enhances the fundamental understanding of cell biology but also opens new avenues for diagnostics and therapeutics in precision medicine.